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| CAS:1606994‑55‑1:Elamipretide TFA | |
| Elamipretide (also known as SS‑31, MTP‑131) is a new‑generation mitochondria‑targeted antioxidant tetrapeptide. It specifically binds to cardiolipin on the mitochondrial inner membrane and enriches inside mitochondria, precisely scavenges mitochondrial reactive oxygen species, inhibits mitochondrial permeability transition pore opening, improves mitochondrial respiratory chain function and ATP production, and reduces apoptosis induced by oxidative stress. It exerts significant protective effects on myocardial ischemia‑reperfusion injury, neurodegeneration, renal injury and aging‑related mitochondrial dysfunction. The trifluoroacetate salt is an HPLC purification intermediate with good water solubility. | |
| 95%/98%/99% | |
| C₃₃H₄₉N₉O₅ | |
| 651.80, higher for TFA salt form | |
| Function Tags (comma-separated) | ||||||||
| Elamipretide TFA; SS-31; MTP-131 | Mitochondrial targeting, Antioxidant, Mitochondrial protection, Ischemia-reperfusion injury, Anti-aging, Neuroprotection | D-Arg-2',6'-dimethyl-L-Tyr-L-Lys-L-Phe-NH₂ | 651.39 | 651.8 | D-amino acid + unnatural amino acid + C-terminal amidation |
| Long-term Storage Conditions | Short-term Storage Conditions | ||||
| PEP-ELA001 | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles and strong oxidizing environment | Stable for 1 month at 2-8℃ sealed & dry; ice pack shipping recommended | Stable for 7 days at 4℃; stable for 2 months at -20℃ in aliquots. **Excellent water solubility, freely soluble in water and physiological buffer**. D-amino acids and terminal modifications significantly enhance enzymatic resistance; dimethyltyrosine site should avoid strong oxidants | Stable for 3 years at -20℃ under dry & dark conditions |
| Applicable Research Areas (comma-separated) | ||||
| PEP-ELA001 | Mitochondria-targeted tetrapeptide that precisely enriches in mitochondria, scavenges ROS and improves respiratory function to protect cells | Elamipretide specifically recognizes and binds to cardiolipin molecules on the mitochondrial inner membrane via its cationic and hydrophobic amphipathic structure, and highly enriches at the mitochondrial matrix side, with a target concentration much higher than the cytosolic level. It directly scavenges reactive oxygen species such as superoxide anions and hydroxyl radicals produced by mitochondria via the dimethyltyrosine residue, while inhibiting the opening of mitochondrial permeability transition pore (mPTP), maintaining mitochondrial membrane potential and structural integrity, improving respiratory chain complex function, increasing ATP production efficiency, and reducing apoptosis and tissue damage mediated by oxidative stress. It shows significant organ protective effects in models of myocardial ischemia-reperfusion, cerebral ischemia, acute kidney injury and neurodegenerative diseases, and is a core tool peptide for the study of mitochondrial dysfunction-related diseases. | Mitochondrial function study, Ischemia-reperfusion injury, Neurodegenerative diseases, Myocardial protection, Renal injury, Anti-aging research |
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